About KINERET
How KINERET works
KINERET is the recombinant form of interleukin-1 receptor antagonist (IL-1Ra), which treats autoinflammation by1:
- Supplementing naturally occurring endogenous IL-1Ra
- Competitively binding to the IL-1 type 1 receptor (IL-1R1)
- Blocking the activity of IL-1 cytokines that trigger the IL-1 inflammatory cascade
The effects of IL-1
Elevated levels of IL-1 may be responsible for symptoms such as:
- Cartilage degradation2
- Bone resorption2,3
- Other autoinflammatory symptoms4-7

IL-1RAcP, interleukin-1 receptor accessory protein.

View the mechanism of action video to see how KINERET works